Gregg's Diet Shack
  • Journey
    • My Health >
      • Genome
      • ACC Fight
    • Chris' Journey
    • About me >
      • Personality
      • Politics
  • Basics
    • Discussions by Subject >
      • A-I >
        • Agriculture
        • Anti-nutrients
        • Antioxidants
        • Brain - Key to Keto-Adaptation
        • Carnivory >
          • Carnivore Science Video
        • Cholesterol
        • CICO
        • Coffee
        • Dental >
          • Dental Caries and Carbohydrates
        • Deuterium
        • Dietary vs Liver made fats
        • Fiber >
          • Fiber Menace
        • Gluten
        • Insulin Resistance
      • J-Z >
        • Ketosis
        • Light and Health
        • Methylation
        • Mitochondria
        • Nutrients >
          • Carbohydrate >
            • Glucose
          • Fat >
            • Saturated Fat
          • Protein >
            • Protein Leverage Hypothesis
          • Nutrients - Plant vs Animal Sources
          • Potassium
        • Obesity
        • Salt gets its own page
        • Soy - Western A. Price
        • Statins
        • Uric Acid
        • Vaccines
        • Vegetarianism >
          • Vegetarians Have Smaller Brains
        • Vitamins >
          • D
          • Vitamin C
          • Vitamin D >
            • Covid19-D
            • Slides from Garland's Lecture
          • Vitamin K
    • Foods - Nobody does it better than Georgia Ede >
      • Arachidonic Acid
      • Beef
      • Meat Composition
      • Vegetables
    • The People >
      • Benjamin Bikman
      • Ivor Cummins
      • Georgia Ede MD
      • Phil Escott >
        • Arthritis: The Best Thing That Happened To Me
        • Pure Activity
      • Duane Graveline (SpaceDoc)
      • Barry Groves >
        • Do You Have to be Mental to be a Vegetarian
      • Zoe Harcombe
      • Adele Hite
      • Lierre Keith
      • Hugh Khan
      • Malcolm Kendrick
      • Paul Mabry
      • Malaena Medford >
        • MM On Calories
        • MM On Cancer
        • MM on Covid
        • MM On Feeding Our Young
        • MM On Histamine
        • MM On Ketosis
        • MM On Peanuts
        • MM On Raw Food
        • MM On Sustainability of Food
      • Tom Naughton - Fat Head
      • Tim Noakes
      • L. Amber O'Hearn
      • The Bear - Owsley Stanley
    • Rosedale Lecture
    • All Sorts of Links and Videos
    • The 20 Myths
    • Diet and Nutrition for the Australian People
    • Diet, Nutrition and Biochemistry Blogs and Websites
    • Discussion on the 'life expectancy' myth
    • Micronutrients Veg vs. Meat
    • Human History >
      • Articles
      • Catching Fire
      • How Carnivorous are we
    • The Fat of the Land
  • Diseases
    • Aging
    • Arthritis
    • Cancer >
      • Cancer as a Metabolic Disease
      • Cancer - General
      • Cancer - Breast
      • Cancer - Colon >
        • Cancer - Colorectal (links)
      • Cancer - Pancreatic
      • Cancer Skin >
        • Cancer - Skin - SecondOpinions
      • Carbohydrate and Cancer
    • Covid19
    • Cramp
    • Dementia
    • Diabetes
    • Diverticulosis >
      • Diverticular Disease Information - Barry Groves
    • Fatty Liver
    • Gallstones
    • Gout
    • Heart Disease
    • Kidney Stones
    • Psychological
    • Scurvy
  • The Studies
    • Of mice and men
    • Links to Studies (and Other Knowledge)
    • The Study
    • Uffe Ravnskof Commentary
    • 8 Glasses of Water a Day?
    • Simple Facts
    • To Microwave or Not to Microwave
    • Social Stuff >
      • Political Party Policies On Food Guidelines
    • Gun Stuff >
      • Shooting
    • Climate Science >
      • David Kear Booklet
      • 31000
      • Gerlach-1991
  • Tools
    • Non Diet Tools
  • Blog
    • BUPA >
      • Bupa "Consultation" Documents
    • Greggatshack's Wordpress Blogs
    • Blogs from Malaena Medford
    • Various and Sundry >
      • 42
      • My Session with Savelev
      • My Session With Blocked By Pete Evans
      • Fencing Manual
      • Vic Stone and I on handicapping
      • Betty Megaw
      • Chris Genealogy Test
  • Quotes
  • Forum
  • Gallery
    • HbA1c vs Lipids
  • Recipes
    • Steak
  • Articles
    • The Cure for Diabetes - Men's Health
  • Test Landing Page
  • Contact
  • RDA
    • A-Z of Food
  • Liver Flush
  • Smacking
  • Controversy
    • Controversy-Kathleen
    • SatFat
    • WTFWR
  • Meat
  • Whisky
  • Lentils
  • Chad
  • Index

Alzheimer's and Dementia


Some are now referring to Alzheimer's Disease as Type 3 Diabetes. Is it possible that excess carbohydrates could be the cause of some of our dementia? Scientific discussion article here.

More detailed scholarly article here at the Western Price organisation website. 

Georgia Ede writes about Alzheimer's. 
​The major hallmarks of Alzheimer’s Disease—neurofibrillary tangles, amyloid plaques, and brain cell atrophy—can all be explained by insulin resistance. A staggering 80% of people with Alzheimer’s Disease have insulin resistance or full-blown type 2 diabetes. The connection between insulin resistance and Alzheimer’s Disease is now so firmly established that scientists have started referring to Alzheimer’s Disease as “Type 3 Diabetes.”

​
High Low-Density Lipoprotein Cholesterol Inversely Relates to Dementia in Community-Dwelling Older Adults: The Shanghai Aging Study

Vitamin D and the risk of dementia and Alzheimer disease
​"Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate about the role of vitamin D in nonskeletal conditions."

High carbohydrate diets and Alzheimer's disease.
Alzheimer's disease (AD) is a common, progressive, neurodegenerative disease that primarily afflicts the elderly. A well-defined risk factor for late onset AD is possession of one or more alleles of the epsilon-4 variant (E4) of the apolipoprotein E gene. Meta-analysis of allele frequencies has found that E4 is rare in populations with long historical exposure to agriculture, suggesting that consumption of a high carbohydrate (HC) diet may have selected against E4 carriers. The apoE4 protein alters lipid metabolism in a manner similar to a HC diet, suggesting a common mechanism for the etiology of AD. Evolutionarily discordant HC diets are proposed to be the primary cause of AD by two general mechanisms. (1) Disturbances in lipid metabolism within the central nervous system inhibits the function of membrane proteins such as glucose transporters and the amyloid precursor protein. (2) Prolonged excessive insulin/IGF signaling accelerates cellular damage in cerebral neurons. These two factors ultimately lead to the clinical and pathological course of AD. This hypothesis also suggests several preventative and treatment strategies. A change in diet emphasizing decreasing dietary carbohydrates and increasing essential fatty acids (EFA) may effectively prevent AD. Interventions that restore lipid homeostasis may treat the disease, including drugs that increase fatty acid metabolism, EFA repletion therapy, and ketone body treatment.

An English longitudinal study shows that cognition declines with increasing HbA1c
Picture
APOE ε4, the door to insulin-resistant dyslipidemia and brain fog? A case study
Conclusion
Ketogenic protocols seem to exert powerful modulatory effects on the most treatment-resistant conditions including obese carriers of the APOE ε4 variant who suffer from comorbid mild cognitive impairment and T2DM. Previous clinical trials have demonstrated the neurological efficacy of the KD. The significant improvements in memory, executive function, MetS pathologies, and cerebral metabolic rate demonstrated in this case study are reproducible and could be easily translated to a general population of MetS patients with self-reported impairments in cognition. The novel approach of nutritional modulation to halt brain atrophy and restore cognitive functionality warrants further investigation.
Powered by Create your own unique website with customizable templates.
  • Journey
    • My Health >
      • Genome
      • ACC Fight
    • Chris' Journey
    • About me >
      • Personality
      • Politics
  • Basics
    • Discussions by Subject >
      • A-I >
        • Agriculture
        • Anti-nutrients
        • Antioxidants
        • Brain - Key to Keto-Adaptation
        • Carnivory >
          • Carnivore Science Video
        • Cholesterol
        • CICO
        • Coffee
        • Dental >
          • Dental Caries and Carbohydrates
        • Deuterium
        • Dietary vs Liver made fats
        • Fiber >
          • Fiber Menace
        • Gluten
        • Insulin Resistance
      • J-Z >
        • Ketosis
        • Light and Health
        • Methylation
        • Mitochondria
        • Nutrients >
          • Carbohydrate >
            • Glucose
          • Fat >
            • Saturated Fat
          • Protein >
            • Protein Leverage Hypothesis
          • Nutrients - Plant vs Animal Sources
          • Potassium
        • Obesity
        • Salt gets its own page
        • Soy - Western A. Price
        • Statins
        • Uric Acid
        • Vaccines
        • Vegetarianism >
          • Vegetarians Have Smaller Brains
        • Vitamins >
          • D
          • Vitamin C
          • Vitamin D >
            • Covid19-D
            • Slides from Garland's Lecture
          • Vitamin K
    • Foods - Nobody does it better than Georgia Ede >
      • Arachidonic Acid
      • Beef
      • Meat Composition
      • Vegetables
    • The People >
      • Benjamin Bikman
      • Ivor Cummins
      • Georgia Ede MD
      • Phil Escott >
        • Arthritis: The Best Thing That Happened To Me
        • Pure Activity
      • Duane Graveline (SpaceDoc)
      • Barry Groves >
        • Do You Have to be Mental to be a Vegetarian
      • Zoe Harcombe
      • Adele Hite
      • Lierre Keith
      • Hugh Khan
      • Malcolm Kendrick
      • Paul Mabry
      • Malaena Medford >
        • MM On Calories
        • MM On Cancer
        • MM on Covid
        • MM On Feeding Our Young
        • MM On Histamine
        • MM On Ketosis
        • MM On Peanuts
        • MM On Raw Food
        • MM On Sustainability of Food
      • Tom Naughton - Fat Head
      • Tim Noakes
      • L. Amber O'Hearn
      • The Bear - Owsley Stanley
    • Rosedale Lecture
    • All Sorts of Links and Videos
    • The 20 Myths
    • Diet and Nutrition for the Australian People
    • Diet, Nutrition and Biochemistry Blogs and Websites
    • Discussion on the 'life expectancy' myth
    • Micronutrients Veg vs. Meat
    • Human History >
      • Articles
      • Catching Fire
      • How Carnivorous are we
    • The Fat of the Land
  • Diseases
    • Aging
    • Arthritis
    • Cancer >
      • Cancer as a Metabolic Disease
      • Cancer - General
      • Cancer - Breast
      • Cancer - Colon >
        • Cancer - Colorectal (links)
      • Cancer - Pancreatic
      • Cancer Skin >
        • Cancer - Skin - SecondOpinions
      • Carbohydrate and Cancer
    • Covid19
    • Cramp
    • Dementia
    • Diabetes
    • Diverticulosis >
      • Diverticular Disease Information - Barry Groves
    • Fatty Liver
    • Gallstones
    • Gout
    • Heart Disease
    • Kidney Stones
    • Psychological
    • Scurvy
  • The Studies
    • Of mice and men
    • Links to Studies (and Other Knowledge)
    • The Study
    • Uffe Ravnskof Commentary
    • 8 Glasses of Water a Day?
    • Simple Facts
    • To Microwave or Not to Microwave
    • Social Stuff >
      • Political Party Policies On Food Guidelines
    • Gun Stuff >
      • Shooting
    • Climate Science >
      • David Kear Booklet
      • 31000
      • Gerlach-1991
  • Tools
    • Non Diet Tools
  • Blog
    • BUPA >
      • Bupa "Consultation" Documents
    • Greggatshack's Wordpress Blogs
    • Blogs from Malaena Medford
    • Various and Sundry >
      • 42
      • My Session with Savelev
      • My Session With Blocked By Pete Evans
      • Fencing Manual
      • Vic Stone and I on handicapping
      • Betty Megaw
      • Chris Genealogy Test
  • Quotes
  • Forum
  • Gallery
    • HbA1c vs Lipids
  • Recipes
    • Steak
  • Articles
    • The Cure for Diabetes - Men's Health
  • Test Landing Page
  • Contact
  • RDA
    • A-Z of Food
  • Liver Flush
  • Smacking
  • Controversy
    • Controversy-Kathleen
    • SatFat
    • WTFWR
  • Meat
  • Whisky
  • Lentils
  • Chad
  • Index