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On Histamine Intolerance

21/10/2018

In response to Paleomedicina's statement

Let's have a discussion about histamine intolerance. I just read something that Csaba Tóth had said:
''The histamine question is closely related to the extent of intestinal permeability. In fact, this is not a histamine intolerance, but an extreme degree of histamine production due to agents in the blood stream. If it was high it would take 2-3 years to recover. Meat do that only if there is foreign material. Fats must also be kept clear. In such cases, it is important that we only eat reliable, clean products. Anyway, this is a very misunderstood phenomenon. All researchers it focuses on histamine for , mast cells and macrophages, while the key to the solution is intestinal permeability. Such a patient often needs to measure intestinal permeability. This also provides information on the operation of other biological membranes''.

Malaena Medford
False, on every level. Histamine intolerance is, in fact, an enzyme deficiency in which the body does not produce enough DAO (diamine oxidase) and HNMT (histamine-N-methyl-transferase) to break histamines down like in someone without intolerance. Histamines are a normal immune function of the body and it causes a cascade reaction where the immune system fights off foreign invaters and protects you, but if you are deficient in said enzymes, it becomes chronic and is a double-edged sword.

One correct point: leaky gut can and does cause enzyme imbalance and histamine reaction, and thus assisting your gut in healing can heal some people of histamine intolerance, but not all.

One major factor is gut biome, as some bacteria produce these enzymes, so getting a healthy gut biome is beneficial to this process. I, myself, eat dirt, especially that black mud near rivers. It is filled with beneficial compounds and a full set of healthy microbes that benefit anyone no matter what their lifestyle is. They even sell this stuff in capsules as a probiotic supplement... Altering the biome can effectively "cure" people of this disorder, but like I said above, those with a severe deficiency find that avoidance is the only answer.

Citrus contributes to histamine problems, which means even as a medicine, it should never be used by one suffering this problem.

Chocking it all up to leaky gut is not correct. It is demeaning to the people who have this condition, and claiming they are imagining having a problem at all. They do have an actual disorder, and it is actually studied, and it has been found to be an actual occurrence which afflicts a small number of individuals who end up going fresh meat Carnivore as it alleviates the symptoms.

~~
I know from personal experience how a deficiency in even one enzyme can make life a living Hell. I suffer from porphyria, with traits around hereditary coproporphyria, in which the enzyme coproporphyrinogen oxidase is deficient. I am, consequently, violently sensitive to sunlight and bright lights, and they cause severe burns, rashes, blisters, seizures, nerve pain, spasms, intestinal ruptures, and other symptoms. I am also deficient in disaccharidases, which is the enzyme type that is essential to breaking down carbohydrate, and thus I am severely carbohydrate intolerant and they make me extremely ill in very low amounts; this is linked to autism, which I have, and autistic people thrive on Ketogenic and Carnivore because those lifestyles remove the substance causing their degenerating brain and gut.

~~
Smolinska, S., Jutel, M., Crameri, R., & O'Mahony, L. (2014). Histamine and gut mucosal immune regulation. Allergy, 69(3), 273-281.

Maintz, L., & Novak, N. (2007). Histamine and histamine intolerance. The American journal of clinical nutrition, 85(5), 1185-1196.

Johnston, C. S. (1996). The antihistamine action of ascorbic acid. In Subcellular Biochemistry (pp. 189-213). Springer US.

Martner-Hewes, P. M., Hunt, I. F., Murphy, N. J., Swendseid, M. E., & Settlage, R. H. (1986). Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers. The American journal of clinical nutrition, 44(6), 907-913.

Rosell-Camps, A., Zibetti, S., Pérez-Esteban, G., Vila-Vidal, M., Ferrés-Ramis, L., & García-Teresa-García, E. (2013). Histamine intolerance as a cause of chronic digestive complaints in pediatric patients. Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva, 105(4), 201-207.

Kohn, J. B. (2014). Is There a Diet for Histamine Intolerance?. Journal of the Academy of Nutrition and Dietetics, 114(11), 1860.

Ji, Y., Sakata, Y., Li, X., Zhang, C., Yang, Q., Xu, M., ... & Tso, P. (2013). Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release. American Journal of Physiology-Gastrointestinal and Liver Physiology, 304(8), G732-G740.

Shakir, K. M., Margolis, S., & Baylin, S. B. (1977). Localization of histaminase (diamine oxidase) in rat small intestinal mucosa: site of release by heparin. Biochemical pharmacology, 26(24), 2343-2347.

Luk, G. D., Bayless, T. M., & Baylin, S. B. (1980). Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity. Journal of Clinical Investigation, 66(1), 66.

Hamada, Y., Shinohara, Y., Yano, M., Yamamoto, M., Yoshio, M., Satake, K., ... & Usami, M. (2013). Effect of the menstrual cycle on serum diamine oxidase levels in healthy women. Clinical biochemistry, 46(1), 99-102.

Fukudome, I., Kobayashi, M., Dabanaka, K., Maeda, H., Okamoto, K., Okabayashi, T., ... & Hanazaki, K. (2013). Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats. Medical molecular morphology, 1-8.

Ferstl, R., Frei, R., Schiavi, E., Konieczna, P., Barcik, W., Ziegler, M., ... & O'Mahony, L. (2014). Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes. Journal of Allergy and Clinical Immunology, 134(3), 744-746.

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Calories Don't Matter

7/10/2018

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This is long, and on calories, and I'm so, so very sorry I am a motormouth on this...but it is so very important that people understand this concept!

All right, I keep getting CICOpaths out there, the ones who vehemently believe in the calories in/calories out myth. There is plenty of evidence to show it's fake, and I am posting a thing I did to explain it. Feel free to ask questions if any of it is confusing.

Calories are a unit of energy which were "discovered" by placing food items in a little oven called a calorimeter, then setting it on fire to boil water and measure each unit of heat created by 1 kelvin.

There's the first problem with "calories" being used for humans. I am not a Bunsen burner. I am not an oven. I don't burn jack squat. Food is metabolized in a complex and immeasurable system of hormonal control and chemical reactivity which science has never and can never measure, especially since each human is completely unique. Unless you are a car, none of that can ever apply to you.

Next problem: Metabolic calories came into the show in the 1920's when an aristocratic woman who practiced binging and anorexia nervosa plucked the term calories out of scientific text and put them in her health book demanding everyone use calories to determine weight. She then came up with an eating plan of restriction, not fasting, in which people actively practice anorexia nervosa. This practice was tested by the one and only Ancel Keys, who showed that calorie restriction may cause weight loss, but it causes physical damage and deterioration too.

The next one is the matter of Taubes' work, which is based on empirical evidence in which "calories" cannot be true because they cause completely different hormonal responses and also cause completely different reactions to each individual.

This can be seen in a little experiment I and several others did, in which we consumed meat and fat (some did plants) for at least 21 days in the amount of 5000+ calories every single day, and all of us not only lost weight, we broke our stalls and the weight lost was rapid. I went down 5 pants sizes. I still eat that much. But if I eat 1200 calories in plants, I will rapidly gain weight.

So why is this?
Because weight gain is determined by inflammation, hormones, and genetics, not mythical little units of energy that are only a reality for ovens and not biological creatures.

Here, we see that they explain that the adipose tissue is an active endocrine organ with hormone secretion and all, and we see that obesity is a form of low-grade inflammation. This is cyclical, in which we can also see that inflammation causes weight gain in the first place, and the swollen adipose increases the weight gain. Now why does it do this? To protect the body. Adipose is a protective organ, and those with subcutaneous fat but no visceral are protected, but it does weigh down their bodies and cause problems. An issue here is this idea that we're getting to much of something, because though obese people are big, they are emaciated like holocaust victims under all that blubber. They are literally starving to death packed in fat. Calories don't come into play at all because it's based on energy, and we aren't made of energy. Fat does not cause fat gain, and in fact causes the opposite, unless you happen to have a disease that causes adipose swell such as hypothyroidism.

Obesity and inflammation: the effects of weight loss
https://www.cambridge.org/…/7DE5BD1B13C41487F6DE50B8DD19220F
[Following the discovery of TNF-α and leptin as secretory products of adipocytes in the early 1990s, subsequent obesity research focused on the new functional role of adipose tissue, as an active endocrine organ. Many more inflammatory peptides have been linked to adiposity, which ultimately characterised obesity as a state of low-grade systemic inflammation, or ‘metaflammation’ which may link obesity to its co-morbidities.]

~ Following? Weight gain is inflammation, not just storing fat. The type of weight gain referred to here is the inflammatory kind and this is not associated with plate fat, but consumption of items the body produces antibodies for, which also attack the person's own tissues.

Inflammation-sensitive plasma proteins are associated with future weight gain.
https://www.ncbi.nlm.nih.gov/pubmed/12882928

Fibrinogen, Other Putative Markers of Inflammation, and Weight Gain in Middle‐aged Adults—The ARIC Study
https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2000.33

Association of Body Mass Index, Body Fat, and Weight Gain With Inflammation Markers Among Rural Residents in Japan
https://www.jstage.jst.go.jp/artic…/…/67/4/67_4_323/_article

Now, what can cause inflammation? Well, that one's easy:
The Dietary Intake of Wheat and other Cereal Grains and Their Role in Inflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705319/

And here's a whopper of a deception pulled on the public:
">>Page 545, paragraph 1:
"Skim milk is one of the most valuable adjuncts of the farm for fattening swine. Used with corn, kafir corn or any of the common grain by-products an almost ideal ration is formed. Hogs like it and relish rations mixed with it. As a result of five years' work in feeding skim milk at the New York station at Cornell, it is concluded that the most economical returns are secured when the milk is fed with corn meal. The proportion of corn meal to skim milk may be varied without apparently affecting the result, but in no case should the amount of skim milk fed be greater than the pigs can quickly and easily consume."<<"
https://www.facebook.com/GroveofWisdom/posts/613303135708568

~Know why they fed them skim? The conjugated linoleic acid in dairy fat has been proven to enhance weight loss, and that would be detrimental to fattening livestock. Now, why are we told something that fattens livestock will make us healthy? And I want to point out it takes very few "calories" of grain to cause weight gain, whereas the same amount of dairy fat would cause the exact opposite and make the piggies lean.

Conjugated linoleic acid (CLA), body fat, and apoptosis.
https://www.ncbi.nlm.nih.gov/pubmed/11316347

Antiobesity Mechanisms of Action of Conjugated Linoleic Acid
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826589/

Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans
https://academic.oup.com/ajcn/article/85/5/1203/4632999

If calories were true, and CICO worked, none of the above studies would be possible. Ever. But there they are, and there they remain. It's just a shame that what is followed is a form of politics and religion rather than the sciences which are completely opposite what is postulated by the same people who told us that grain was a health food instead of letting the farmers tell us it's pig swill for fattening their animals.

There is so much more on this, and I am working on my PhD in this exact area of study. What science says is not anything close to what the nutrition guidelines say. The guidelines made people fat, so why are we still listening to them?

Now, what happens when we avoid fat? Anyone? No? Simply put, our bodies have chemicals and hormones to detect fat input. The less fat we put in our bodies, the less fat we will oxidize, ergo, "fat is a lever" should actually be seen as the truth, where removing plate fat shuts off fat metabolism. Eventually this rebounds and people end up re-gaining that weight, sometimes more than what they had before.

This is explained by the good man Paul Mabry, who has been studying the effects of fat restriction and has come up with some pretty shocking conclusions in which science shakes the very foundation of the nutrition religion and shows that everything you think you know, is entirely wrong.

The gut has a receptor to tell us when fat is plentiful, and when it needs to be saved because it's not coming in:
https://www.facebook.com/GroveofWisdom/posts/619644645074417
~I also give my own input with some studies that show that fat increase causes fat metabolism to go up, not down. The only studies that show high-fat causing weight gain are also high-carb, because you cannot have weight gain on high-fat without specific conditions as mentioned before. This is hormonal.

Oh, and before I get the whole "but calorie restriction works!" Well of course, anorexia nervosa will always cause weight loss. That doesn't mean it's healthy nor acceptable. Why would someone intentionally force their child to starve to death, only giving them enough of the poison causing the weight gain to keep them alive but miserable, without wondering if what they are doing is even remotely sane? They listen to the "authorities" blindly, without asking why people are still dying of disease, and then they don't even see the statistics where people who are skinny have just as many if not more incidences of heart disease as obese people.

Anyone see that article where that man from "The Biggest Loser" had a heart attack on his low-fat, exercise-intense lifestyle? Then he blamed...fat! He blamed something he actively avoids.

Then we see things like this:
A risk you can't run off: How celebrity fitness guru and Biggest Loser host suffered a heart attack due to genetics
https://www.dailymail.co.uk/…/A-risk-run-Heart-attack-cause…
Absolute nonsense. He suffered from his nutrient-deficient diet in which low vitamin K2, A, and possibly D3 caused his arterial calcium to skyrocket and it made him have a heart attack.

And Ivor Cummins explains this one in perfect detail with actual models which show the accuracy of this method, along with a video with the explanation of fat being protective, unless it's excessive visceral:

CAC CALCIUM, THE ULTIMATE TEST FOR ATHEROSCLEROSIS...CHALLENGES LDL AS CAUSE!
http://www.thefatemperor.com/…/cac-calcium-the-ultimate-tes…

FoodNews Conference 2018 - fixing the Heart Disease Elephant !
https://www.youtube.com/watch?v=1H889DhAYwc

Here's the thing about calorie restriction. Weight loss does not automatically mean health gain. It can mean the exact opposite. Just because the scale goes down, does that mean the health markers go up? Do you really care more about vanity and appearance than your health? Fixing health almost always causes weight loss. For some, this is a challenge none of us will even begin to understand, and they have to keep pushing through when nothing is working. I work with these people 24/7, and they are delightful people. But I would never give them such shoddy advice as to tell them that calories are even remotely a thing in metabolism.

Examples of trials showing that weight loss is not only not controlled by calories--but by macros--but also showing that weight loss does not mean good health:

A Randomized Trial of a Low-Carbohydrate Diet for Obesity
https://www.nejm.org/doi/full/10.1056/NEJMoa022207
[The low-carbohydrate diet produced a greater weight loss (absolute difference, approximately 4 percent) than did the conventional diet for the first six months, but the differences were not significant at one year. The low-carbohydrate diet was associated with a greater improvement in some risk factors for coronary heart disease.]

The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial.
https://www.ncbi.nlm.nih.gov/pubmed/15148064?dopt=Abstract
[Participants on a low-carbohydrate diet had more favorable overall outcomes at 1 year than did those on a conventional diet. Weight loss was similar between groups, but effects on atherogenic dyslipidemia and glycemic control were still more favorable with a low-carbohydrate diet after adjustment for differences in weight loss.]

Effects of Low-Carbohydrate and Low-Fat Diets
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428290/
[The low-carbohydrate diet was more effective for weight loss and cardiovascular risk factor reduction than the low-fat diet. Restricting carbohydrate may be an option for persons seeking to lose weight and reduce cardiovascular risk factors.]

A Randomized Pilot Trial of a Moderate Carbohydrate Diet Compared to a Very Low Carbohydrate Diet in Overweight or Obese Individuals with Type 2 Diabetes Mellitus or Prediabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981696/
[Our results suggest that a very low carbohydrate diet coupled with skills to promote behavior change may improve glycemic control in type 2 diabetes while allowing decreases in diabetes medications.]

A non-calorie-restricted low-carbohydrate diet is effective as an alternative therapy for patients with type 2 diabetes.
https://www.ncbi.nlm.nih.gov/pubmed/24390522
[Our findings suggest that a low-carbohydrate diet is effective in lowering the HbA1c and triglyceride levels in patients with type 2 diabetes who are unable to adhere to a calorie-restricted diet.]

Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome.
https://www.ncbi.nlm.nih.gov/pubmed/18396172
[From the current state of the literature, however, low-carbohydrate diets are grounded in basic metabolic principles and the data suggest that some form of carbohydrate restriction is a candidate to be the preferred dietary strategy for cardiovascular health beyond weight regulation.]

Endurance athletes who 'go against the grain' become incredible fat-burners
https://www.sciencedaily.com/releas…/2015/…/151117091234.htm
[Elite endurance athletes who eat very few carbohydrates burned more than twice as much fat as high-carb athletes during maximum exertion and prolonged exercise in a new study -- the highest fat-burning rates under these conditions ever seen by researchers.]

And thus, we can come to the conclusion within the standards of scientific rigor that calorie restriction is not, in fact, something which should be praised nor adhered to. In every instance, weight loss did bupkis and these people were just as likely to die from heart disease as they were, before, and could even be at a higher risk because now they are severely deprived of essential nutrients and their arteries are loaded with calcium from deficiency of fat-soluble vitamin K2.
Again I ask, is vanity really more important than health?

A little more…

And fat? It's not "burned", it's not simply fuel, it's nothing as described to us by the authorities at all. Until you turn into a machine which practices combustion of fuel, forget all that nonsense. Fat is used as a material to create metabolites which are used for chemical and hormonal processes, as well as used to create new tissues in the body. Our body is majorly composed of phospholipid bilayers - phosphorus, fat, and cholesterol, with about an equal amount of protein. We're made of fat, and it's just as important to cellular development and health as protein, and is just as much of a building block of every system in our body as amino acids. Our brains are made of fat and cholesterol, and the body does not choose body fat when plate fat is restricted, it actually slows and the metabolism tanks, causing stalls and holding onto fat. Based on biochemistry, fat is not a fuel, nor is it "empty calories" or "calories" at all, it's a vital material used in various processes, which happens to include energy but is a small part of the importance of dietary fat.
Does this mean there's no such thing as too much fat? No. This is entirely subjective to each and every individual and must be tailored based on personal reaction, but has absolutely nothing to do with "calories".

Increasing Dietary Fat Elicits Similar Changes in Fat Oxidation and Markers of Muscle Oxidative Capacity in Lean and Obese Humans
[In response to an isoenergetic increase in dietary fat, whole-body fat oxidation similarly increases in LN {lean} and OB {obese}, in association with a shift towards oxidative metabolism in skeletal muscle, suggesting that the ability to adapt to an acute increase in dietary fat is not impaired in obesity.]

~ Ergo, fat oxidation is almost entirely identical when fat was increased, not slowed or stopped in the people with extra packing in the trunk. They oxidized fat the same as the skinnies.

Now, when we eat fat or have fat, where does it go when we lose it if we don't burn it? We've been misinformed to think that we're machines, and that a fire which cannot be located anywhere in the body gulps in a specific amount of fat and burns it, then… Well, it ends there, because they don't actually tell you what happens to it, do they? I present to you, the answer: You breathe 80% or so of it out as carbon dioxide, and the rest is turned into ketones, water, or free-floating hydrogen ions to keep your body in balance, called homeostasis, along with many other things necessary for you to live. The idea that we burn it or use plate fat goes against everything in biological sciences and human physiology. It simply cannot happen.

When somebody loses weight, where does the fat go?
https://www.bmj.com/content/349/bmj.g7257

Explanation of the beginning of calories and metabolism:
https://www.businessinsider.com/calories-not-perfect-nutrit…

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Notes From Malaena

On Histamine Intolerance

Calories Don't Matter

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