On Histamine Intolerance

In response to Paleomedicina's statement

• Let's have a discussion about histamine intolerance. I just read something that Csaba Tóth had said:
  ''The histamine question is closely related to the extent of intestinal permeability. In fact, this is not a histamine intolerance, but an extreme degree of histamine production due to agents in the blood stream. If it was high it would take 2-3 years to recover. Meat do that only if there is foreign material. Fats must also be kept clear. In such cases, it is important that we only eat reliable, clean products. Anyway, this is a very misunderstood phenomenon. All researchers it focuses on histamine for , mast cells and macrophages, while the key to the solution is intestinal permeability. Such a patient often needs to measure intestinal permeability. This also provides information on the operation of other biological membranes''.

Malaena Medford
False, on every level. Histamine intolerance is, in fact, an enzyme deficiency in which the body does not produce enough DAO (diamine oxidase) and HNMT (histamine-N-methyl-transferase) to break histamines down like in someone without intolerance. Histamines are a normal immune function of the body and it causes a cascade reaction where the immune system fights off foreign invaters and protects you, but if you are deficient in said enzymes, it becomes chronic and is a double-edged sword.

One correct point: leaky gut can and does cause enzyme imbalance and histamine reaction, and thus assisting your gut in healing can heal some people of histamine intolerance, but not all.

One major factor is gut biome, as some bacteria produce these enzymes, so getting a healthy gut biome is beneficial to this process. I, myself, eat dirt, especially that black mud near rivers. It is filled with beneficial compounds and a full set of healthy microbes that benefit anyone no matter what their lifestyle is. They even sell this stuff in capsules as a probiotic supplement... Altering the biome can effectively "cure" people of this disorder, but like I said above, those with a severe deficiency find that avoidance is the only answer.

Citrus contributes to histamine problems, which means even as a medicine, it should never be used by one suffering this problem.

Chocking it all up to leaky gut is not correct. It is demeaning to the people who have this condition, and claiming they are imagining having a problem at all. They do have an actual disorder, and it is actually studied, and it has been found to be an actual occurrence which afflicts a small number of individuals who end up going fresh meat Carnivore as it alleviates the symptoms.

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I know from personal experience how a deficiency in even one enzyme can make life a living Hell. I suffer from porphyria, with traits around hereditary coproporphyria, in which the enzyme coproporphyrinogen oxidase is deficient. I am, consequently, violently sensitive to sunlight and bright lights, and they cause severe burns, rashes, blisters, seizures, nerve pain, spasms, intestinal ruptures, and other symptoms. I am also deficient in disaccharidases, which is the enzyme type that is essential to breaking down carbohydrate, and thus I am severely carbohydrate intolerant and they make me extremely ill in very low amounts; this is linked to autism, which I have, and autistic people thrive on Ketogenic and Carnivore because those lifestyles remove the substance causing their degenerating brain and gut.

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